Nonsedating muscle relaxant
On days 0, 28, and 56, six volunteers had skin tests hourly for 12 hours after the morning terfenadine dose.On all study days, serum terfenadine metabolite I concentrations were measured each time histamine skin tests were performed. In many cases, these side effects are dose-dependent and attenuate with time. Benzodiazepenes and other sedatives/anxiolytics 11. Medication side effects that can affect driving performance include drowsiness, dizziness, blurred vision, unsteadiness, fainting, slowed reaction time, and extrapyramidal side effects.Combinations of drugs may affect drug metabolism and excretion to produce additive or synergistic interactions.In fact, use of multiple psychoactive medications is a common cause of hospitalization for delirium among older adults. wine) has the potential to impair driving performance in many individuals. Stimulants Many commonly used prescription and over-the-counter medications can impair driving performance.
He/she should also recommend that the patient take the first few doses in a safe environment to determine the presence and extent of any side effects, and that he/she temporarily cease driving as needed until the body has adjusted to the medication.
Oral second generation antihistamines inhibit histamine dependent activation of nasal H1-receptors.
They mainly reduce nasal itch, sneezing, and hypersecretion.
If the physician must prescribe or change the dosage of a medication that can potentially impair driving performance, he/she should counsel the patient regarding the side effects.
Whenever possible, the physician should prescribe non-impairing medications.
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In the case of these medications, the concerned physician and patient may wish to consider formal psychomotor testing (up to and including driving simulation) or driver evaluation (including on-road assessment) performed by a driver rehabilitation specialist, while off and on the medication to determine the extent of impairment.